Research Associate/Fellow (Mass Spectrometry Analysis of Organic Surfaces and Interfaces) (Fixed term)

Vacancy Reference Number

SCI595122

Organisation:

University of Nottingham

Closing Date

30 Jan 2023

Salary

£28,762 to £35,333 per annum (pro rata if applicable) depending on skills and experience (minimum £32348 with relevant PhD).

Address

University of Nottingham, School of Pharmacy

Duration

3 years

This post will employ electrospray-based surface analysis and mass spectrometry approaches such as Liquid Extraction Surface Analysis (LESA), and LC-MS based metabolomics. The successful candidate will be responsible for analysing the secretome from cells exposed to a range of topography/chemistry combinations. This post is available on a 3 year fixed term contract. Hours of work are full time (36.25 hour). Job share arrangements may be considered. Informal enquiries may be addressed to Rian Griffiths (email: rian.griffiths@nottingham.ac.uk). Please note that applications sent directly to this email address will not be accepted.

Further Information

This is one role we are recruiting to support our EPSRC funded project: Designing bio-instructive materials for translation ready medical devices.

We are seeking postdoctoral scientists to join an EPSRC funded project that will design and synthesise bio-instructive materials to manufacture translation ready medical devices.

A novel class of polymers developed in our labs show great promise in reducing infections and controlling host response in the clinic. We recently added the use of micro topography to provide a synergistic stimulus to tackle infections and found an improvement in the host immune response. This control of host response is applicable to achieving better implant integration and wound healing. These findings are being developed in this project to improve outcomes for medical devices in the clinic.

In this EPSRC funded project we will use combinatorial material libraries in ChemoTopo Chips using cutting edge 3D printing technologies. These will be employed to both discover new ‘immune-instructive’ chemistry:topography combinations and probe the mechanisms that underpin their cell-instructive ability. We will develop models across a range of surfaces which correlate polymer molecular structure, surface chemistry, topography, manufacturing fidelity and bio-interfacial composition with immune and stromal cell responses as well as bacteria biofilm resistance. These models will be used to design optimal materials and manufactung strategies for use in implanted surgical meshes and chronic wound care products for the post antibiotic era.

This is a collaborative project between the Schools of Pharmacy, Computer Science, Physics and Astronomy, Life Sciences and the Faculty of Engineering.

Please refer to the University of Nottingham Vacancy information here for role profile and application portal:

https://jobs.nottingham.ac.uk/Vacancy.aspx?ref=SCI595122

Contact Details

rian.griffiths@nottingham.ac.uk

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