PhD Studentship

Vacancy Reference Number

UoN-RLG

Organisation:

University of Nottingham

Closing Date

10 Dec 2021

Salary

£15,609 per annum

Address

University of Nottingham

Duration

3.5 years, from February 2022

This 3.5 year PhD project, based in the School of Pharmacy, utilises state-of-the-art instrumentation acquired in recent years. Advanced high mass resolution (Orbitrap) instrumentation will be utilised for the analysis of lipids from bacterial samples. Surface mass spectrometry and imaging techniques such as atmospheric pressure (AP) matrix-assisted laser desorption/ionisation (MALDI) and secondary ionisation mass spectrometry (SIMS) will be considered.

This multi-disciplinary project combines analytical science with physical sciences and chemical sciences. The project will be highly analytical with a focus on understanding lipid ion formation via different ionisation processes and routes to improving these. Furthermore, biological and medical sciences will play a key role in understanding differences in lipid signatures from bacterial samples.

This project seeks to make the most of the world leading capabilities and instrumentation available at the University of Nottingham, particularly ambient ionisation, high mass resolution instruments and data analysis.

Further Information

Antimicrobial resistance (AMR) threatens to rival cancer in mortality and financial burden by 2050. Mycobacterial infections are the primary bacterial cause of global morbidity and mortality (2 million deaths annually), costing $12 billion, with lipids implicated in AMR. It is imperative to have sensitive detection and identification methods directly from biological samples. This project will develop surface mass spectrometry and imaging analysis methods for lipids that are indicative of disease/progression and impact therapeutic strategies/success.

The successful candidate will:
-receive the training needed for a professional career as a multidisciplinary analytical scientist
-receive a full studentship tax free (fees and stipend at UK/EU rates) for 3.5 years
-work directly with leading academics
-receive a travel and consumable allowance

Due to funding restrictions, the position is only available for UK candidates. Funding is available for 3.5 years commencing February 2022.

Candidates must possess or expect to obtain, a 2:1 degree in Physics, Chemistry, Biology or a related scientific discipline. The project is particularly suitable for candidates with a scientific background who would like to develop their analytical skills.

https://www.nottingham.ac.uk/pharmacy/study/phd-vacancies/euuk.aspx#RianGriffiths

Contact Details

Dr Rian Griffiths (rian.griffiths@nottingham.ac.uk)