Mass Spectrometry Imaging - Drug Distribution and Host Response in TB Infected Tissues
- Vacancy Reference Number
- MSI - Drug Distribution and Host Response
- Closing Date
- 1 Jun 2019
- Salary
- competitive salary based on experience
- Address
- Hackensack Meridian Health Center for Discovery and Innovation, 340 Kingsland Street, Building 102, Nutley, NJ 07110, USA
- Duration
- 2 years
The Hackensack Meridian Health Center for Discovery and Innovation (CDI) is offering a postdoctoral research position in the field of mass spectrometry imaging (MSI) applied to anti-infective drug discovery and development.
The position will be in the laboratory of Dr. Veronique Dartois, an expert in tuberculosis (TB) infection and antimicrobial therapy, working under the direct supervision of Dr. Claire Carter, an expert in MALDI-MSI. The lab is interested in drug discovery against multidrug resistant TB infections, mechanisms of drug resistance, and studies of drug penetration and action at sites of infection.
Key areas of focus include:
- Operate and maintain instrumentation (Solarix, Orbis and LCMs) within Biosafety Level 3 (BSL-3) and BSL2 facilities.
- Design and develop novel sample preparation methodologies to enhance sensitivity and maintain tissue morphology for drug, metabolite and lipid distribution studies.
- Tissue handling and cryo-sectioning within BSL2/3 facilities
- Process data using a variety of vendor-based and open-source software. The research program incorporates clinical, preclinical and translational research aimed towards eradication of infectious disease causing pathogens. The successful postdoctoral candidate will have a strong interest in utilizing novel analytical technologies for drug discovery and development targeting infectious diseases.
The postdoctoral fellow is expected to understand the project and work independently taking responsibilities in the development and execution of experimental procedures to successfully advance the research project. The successful candidate will be responsible for preparation of data for presentations, progress reports, and the preparation of manuscripts. The post-doctoral fellow is anticipated to have good communication and writing skills with a mind-set for collaborative research. The CDI is located in New Jersey, a known hub for pharmaceutical research, and is 12 miles from midtown Manhattan. It is easily accessible by public transportation.
Further Information
Example Publications:
1. Prideaux, B., et al., The association between sterilizing activity and drug distribution into tuberculosis lesions. Nat Med, 2015. 21(10): p. 1223-7. https://www.ncbi.nlm.nih.gov/pubmed/26343800
2. Blanc, L., et al., Impact of immunopathology on the antituberculous activity of pyrazinamide. J Exp Med, 2018. 215(8): p. 1975-1986. https://www.ncbi.nlm.nih.gov/pubmed/30018074
3. Blanc, L., et al., High-resolution mapping of fluoroquinolones in TB rabbit lesions reveals specific distribution in immune cell types. Elife, 2018. 7. https://www.ncbi.nlm.nih.gov/pubmed/30427309
HMH-CDI website:
https://hmh-cdi.org/
Contact Details
Applications should be addressed to:
Dr. Claire Carter
clc326@njms.rutgers.edu