Post Doc – Mass Spectrometry (LifeArc Fellowship)

Vacancy Reference Number

VA13

Closing Date

3 May 2019

Salary

Competitive Salary

Address

Medicines Discovery Catapult Block 35G Alderley Park SK10 4TG

Duration

2 Years

We are looking for a post-doctoral scientist with significant experience in mass-spectrometry and expertise in MS proteomics to deliver this research project. The successful individual will establish novel methods & workflows, utilising the cutting-edge technology platforms available at MDC, and will apply them in collaborative projects to address biological questions and further LifeArc’s portfolio of drug discovery projects.

Main duties and responsibilities -Establish novel biological mass spectrometry workflows in cells and tissues, through de novo method development and adaptation of existing Catapult protocols.

-Apply these methods in target engagement, target validation and mechanism-of-action studies focussed on LifeArc projects and lead molecules.

-Deliver targeted and untargeted mass spectrometry studies to measure proximal and global changes in response to drug treatment.

-Analyse target protein expression and elucidate the target protein complex, for example through application of immunoprecipitation methods to pull down target proteins.

-Apply pre-commercial mass-spectrometry technologies available at MDC (e.g. acoustic mist ionisation mass-spectrometry) to develop novel protocols that can be applied to medicines discovery.

-Deliver high quality data in a complex and time pressured research team environment -Implement effective lab processes, experimental records and safety.

-Demonstrate effective communication and research collaboration skills, working routinely with colleagues across both the Catapult and LifeArc organisations.

-Communicate results, through publication and external presentation.

Qualifications and Experience -The successful candidates will possess a PhD and preferably post-doctoral experience, working with mass spectrometry in a bioscience or medicines discovery environment -Proven expertise in biological mass-spectrometry, including mass-spec proteomics, demonstrated by a track record of delivery and a strong publication record -Experience of working with nano-HPLC and high-resolution mass-spectrometry -Track record of establishing novel methods and workflows -Experience in data analysis, handling and interpretation -Experience in cell culture -Ability to work on multiple projects simultaneously in a highly collaborative and inter-disciplinary environment

Further Information

Job Description:
https://md.catapult.org.uk/vacancy/post-doc-mass-spectrometry-lifearc-fellowship/

Apply at:
https://mdc.peoplehr.net/Pages/JobBoard/Job.aspx?v=7e4edb5e-f9e9-4f3a-8dc5-51de533b9ec9

Contact Details

recruitment@md.catapult.org.uk